Lifespan Extension Protocol
Rapamycin
Rapamycin (Sirolimus) is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.
How does it work?
Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:
mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.
Reduces Inflammaging
• Rapamycin lowers chronic low-grade inflammation and may reduce risk of diseases like cancer, Alzheimer’s, cardiovascular disease, and metabolic syndrome.
Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.
Benefits
✓ May extend lifespan and delay age-related disease
✓ Supports cellular autophagy and DNA repair
✓ Reduces chronic inflammation (“inflammaging”)
✓ Improves metabolic health and insulin sensitivity
Take the health questionnaire
Get your prescription
Get your meds
Frequently Asked Questions
What can I expect with Rapamycin treatment?
Week 2–4: Subtle improvement in recovery, inflammation, skin tone
• Week 6–12: Better metabolic flexibility, energy, and clarity
• 6–12 months: Long-term benefits on insulin sensitivity, lipid markers, and cellular health
• Optimal when combined with Metformin, exercise, time-restricted eating, NAD+ support
• Missed dose? Take on your next scheduled day—do not double dose
What are the possible side effects of Rapamycin?
Common (Usually mild at low/intermittent doses):
• Mouth ulcers or canker sores
• Gastrointestinal discomfort
• Headache or fatigue
• Mild immunosuppression (dose-dependent)
Less Common / Monitor If Present:
• Elevated triglycerides or cholesterol
• Impaired wound healing
• Increased risk of infection at high doses
• Menstrual irregularities